Ting Therapeutics Advances TT004 into Phase Ib Clinical Trials as a Potential Cisplatin Chemoprotective Therapy
Oct 23, 2026
San Diego, California Oct 22, 2026 (Issuewire.com) - Ting Therapeutics Advances TT004 into Phase Ib Clinical Trial as a Potential Chemoprotective Therapy for Cisplatin-Treated Patients
- China IND Approved;
- Phase Ib Trial Set to Begin Recruiting Patients at Eye and ENT Hospital of Fudan University in Shanghai
Ting Therapeutics, Inc., a biotechnology company developing therapies for treatment-related tissue injury, today announced that its lead candidate, TT004, has received IND approval in China and is advancing into Phase Ib clinical development as a potential chemoprotective therapy for patients receiving cisplatin chemotherapy.
Cisplatin is a highly effective cancer treatment, but its toxicities can substantially limit therapy. Approximately 40% of patients discontinue or modify chemotherapy because of treatment-related toxicities. Cisplatin can also cause permanent hearing loss in up to 80% of patients and acute kidney injury in approximately 30% of patients.
TT004 is designed to protect normal tissues from cisplatin toxicity while preserving its anticancer activity. In preclinical studies, TT004 increased survival following cisplatin exposure three-fold and reduced cisplatin-induced hearing loss and kidney injury by approximately 70%, without compromising cisplatin's anticancer effects.
"These findings support our vision of TT004 as a chemoprotective therapy that could improve the tolerability of cisplatin while maintaining its anticancer efficacy," said Jian Zuo, PhD, Co-Founder and CEO of Ting Therapeutics. "Our goal is to reduce the suffering caused by cisplatin treatment-related toxicities, help more patients receive and complete effective chemotherapy, and improve their long-term quality of life."
Ting Therapeutics recently licensed its China rights for TT004 to Rising Dragon, a Chinese biotechnology company, for development in China. The companies jointly developed TT004 as an oral tablet and obtained IND approval from China's Center for Drug Evaluation (CDE) for first-in-human clinical evaluation.
The Phase Ib trial, conducted in collaboration with oncologists and otolaryngologists at Eye and ENT Hospital of Fudan University in Shanghai, will evaluate the safety and tolerability of oral TT004 administered with standard-of-care cisplatin chemotherapy in patients with head and neck cancer. The study has received institutional ethics approval and is preparing to initiate patient recruitment.
TT004's protective effects have been demonstrated only in preclinical models and have not yet been shown in humans. This trial is the first clinical evaluation of TT004 and an important step toward determining whether these effects can be translated to cancer patients.
About Ting Therapeutics
Founded in 2018, Ting Therapeutics, Inc. develops novel and repurposed therapeutics to prevent and treat hearing loss and other treatment-related tissue injuries. The Company's pipeline targets hearing loss associated with chemotherapy, noise exposure, antibiotics, aging, and other causes.
Contact:
Jian Zuo, PhD, Co-Founder & CEO
Ting Therapeutics, Inc.
6868 Nancy Ridge Dr., San Diego, CA 92121
[email protected]
Source :Ting Therapeutics, Inc.
This article was originally published by IssueWire. Read the original article here.
More News
Hotel Review: Mount Juliet Estate, County Kilkenny
Fresh from an extensive refurbishment, Mount Juliet Estate pairs Georgian character with Michelin-starred dining, championship golf, attentive service and an extraordinary roster of country pursuits across 500 acres in Kilkenny. The post Hotel Review: Mount Juliet Estate, County Kilkenny appeared first on Business Traveller.
American Express Platinum Adds Airbnb Luxe to $600 Lodging Credit
Amex Platinum is venturing beyond hotels. Airbnb Luxe now qualifies for its $600 lodging credit, while a new $250 Experiences benefit sweetens the deal—but one-night FHR stays are losing ground. The post American Express Platinum Adds Airbnb Luxe to $600 Lodging Credit appeared first on Business Traveller.
Hotel Review: The Brazilian Court, Palm Beach
Celebrating its centennial, The Brazilian Court pairs secluded courtyards, residential-style suites and Café Boulud with one of Palm Beach’s best locations, delivering old-world character without feeling frozen in time. The post Hotel Review: The Brazilian Court, Palm Beach appeared first on Business Traveller.
Meet the Judges: Business Traveller Awards 2026
Our global awards were shaped by a panel of experts across the travel, media, design and hospitality industries The post Meet the Judges: Business Traveller Awards 2026 appeared first on Business Traveller.
United Opens Its Largest Airport Lounge in Houston Terminal B
Airport lounges keep getting bigger, and United may have just won the square-footage contest. Houston’s new 54,000-square-foot club seats 800—assuming the crowds do not arrive faster than the furniture. The post United Opens Its Largest Airport Lounge in Houston Terminal B appeared first on Business Traveller.
1st human case of livestock virus Shamonda reported in France
France on Thursday reported the first human case of the Shamonda virus usually found in livestock in a patient who later died, with authorities adding there was no risk to the general population at this stage.
Turkish Airlines Chairman Murat Şeker on Premium, Personalisation and the Path to the Top Three
Turkish Airlines has conquered scale. Now it’s setting its sights on a distinctive guest experience. The post Turkish Airlines Chairman Murat Şeker on Premium, Personalisation and the Path to the Top Three appeared first on Business Traveller.
Help! Why Won’t Travel Insurance Pay for My $17,500 Broken Leg?
An American tourist had emergency surgery in Thailand after tripping and falling at an ice cream counter. Good thing he bought insurance — or so it seemed.
Long COVID patients 'devastated' by impending changes to virtual care access in B.C.
More than 300,000 British Columbians live with long COVID, with many relying on virtual appointments to access the care they need. But health providers are warning impending caps on appointment sizes and changes to fees will create lengthy delays and lead to cutbacks in vital programs.
Vanessa Branson on Her Travel Hacks, Essentials and Favourite Trips
Vanessa Branson has all the hacks from years of international travel. Her top tip? Screenshot everything. The post Vanessa Branson on Her Travel Hacks, Essentials and Favourite Trips appeared first on Business Traveller.
HBO Max K-drama Make Me Tingle: Nam Ji-hyun, Kim Jae-young lead tame sex romcom
Lead cast: Nam Ji-hyun, Kim Jae-young South Korea finds itself at an interesting juncture in its social evolution in the mid-2020s. Following the success of works such as the 2016 book Kim Ji-young, Born 1982 and its hit 2019 film adaptation, which brought the country’s gender inequality into sharp focus, the imbalance remains stubbornly stark. People now recognise this imbalance and are unafraid to label it for what it is – “patriarchy” is no longer a dirty word. Yet change has been slow. South...
YOUR NEWS, OUR NETWORK.
Do you have Great News you want to tell the world?
Be it updates about your business or your community, you can make sure that it’s heard by submitting your story to our network reaching hundreds of news sites across 6 verticals.